US airports recorded their busiest week since the pandemic began
In another television appearance, he recommended Thanksgiving travellers to quarantine for a period of time "if it's possible".
Dr Deborah Birx, White House coronavirus response coordinator, echoed Mr Fauci's concerns, telling CBS News that people who have travelled for the holiday should avoid seeing people over the age of 65.
"Now we're entering this post-Thanksgiving surge with three, four and 10 times as much disease across the country," she said. "We are deeply worried".
Meanwhile, in New York City Mayor Bill de Blasio says schools can reopen in December, weeks after they were shut for a second time. Parents had complained that bars and restaurants were able to operate, but not schools.
And in California, Los Angeles county is imposing a new three-week lockdown from Monday, which will ban most public gatherings and limit the number of people allowed in shops at any one time.
This coming week, the Centres for Disease Control and Prevention is set to discuss the rollout of the vaccine with the Advisory Committee on Immunization Practices.
Mr Fauci said the vaccine offered a "light at the end of the tunnel".
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